Pyrrolidine → HCID 59152279, compound

HRID 1931455Notes

Reaction equation

HRID 1931455 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([S:13][CH2:14][C:15]([OH:17])=O)[S:11][CH:12]=2)=[CH:4][CH:3]=1.[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([S:13][CH2:14][C:15]([N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)=[O:17])[S:11][CH:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 60650053HCID 60650053, compound

Product 1

HCID 59152279HCID 59152279, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.37 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylsulfanyl]-acetic acid and 52.8 mg (0.74 mmol) of pyrrolidine. Yield: 17 mg.

Sources & evidence

ORD record
ord-dbb8cfdef3bb4645a7a1823dd2f97982
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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