3,5-Dimethylisoxazole-4-isocyanate → 1-(3,5-Dimethyl-isoxazol-4-yl)-3-[2-((R)-indan-1-ylamino)-quinolin-6-yl]-urea

HRID 1931498Notes

Reaction equation

HRID 1931498 reaction equation
C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.[Mg+2].[C@H:28]1([NH:37][C:38]2[CH:47]=[CH:46][C:45]3[C:40](=[CH:41][CH:42]=[C:43]([NH2:48])[CH:44]=3)[N:39]=2)[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:30][CH2:29]1.[CH3:49][C:50]1[C:54]([N:55]=[C:56]=[O:57])=[C:53]([CH3:58])[O:52][N:51]=1>>[CH3:49][C:50]1[C:54]([NH:55][C:56]([NH:48][C:43]2[CH:44]=[C:45]3[C:40](=[CH:41][CH:42]=2)[N:39]=[C:38]([NH:37][C@H:28]2[C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH2:30][CH2:29]2)[CH:47]=[CH:46]3)=[O:57])=[C:53]([CH3:58])[O:52][N:51]=1

Participants

4

Reactant 3

HCID 27362663,5-Dimethylisoxazole-4-isocyanateHCID 11418570Magnesium gluconate anhydrousHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 442182691-(3,5-Dimethyl-isoxazol-4-yl)-3-[2-((R)-indan-1-ylamino)-quinolin-6-yl]-urea

Procedure

The title compound, MS: m/e=414.6 (M+H+), was prepared in accordance with the general method 4 of example 16 from (R)—N2-indan-1-yl-quinoline-2,6-diamine and 3,5-dimethylisoxazol-4-yl isocyanate.

Sources & evidence

ORD record
ord-644d9274f6a54419ab48944c765145ac
Source dataset
uspto-grants-2012_05
Patent number
US08188284B2

Reaction notes

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