Methyl iodide → HCID 178512098, compound

HRID 1931513Notes

Reaction equation

HRID 1931513 reaction equation
[C@H:1]1([NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:21][C:22]([NH2:24])=S)[CH:17]=3)[N:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.CI>CC(C)=O.O1CCCC1>[CH2:1]([NH:10][C:22]([NH:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([NH:10][C@H:1]1[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH2:3][CH2:2]1)[CH:20]=[CH:19]2)=[NH:24])[C:9]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 57860960HCID 57860960, compound

Product 1

HCID 178512098HCID 178512098, compoundYield 196.3%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 8028TetrahydrofuranSolvent

Procedure

[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-thiourea (600 mg, 1.8 mmol) was dissolved in 20 mL acetone and 10 mL tetrahydrofurane. Methyliodide (306 mg, 2.2 mmol) was added and the reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated and the residue was recrystallized from dichloromethane and diethylether. The title compound (720 mg, 84%) was obtained as a yellow solid; MS: m/e=349.4 (M+H+).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from dichloromethane and diethylether

Sources & evidence

ORD record
ord-f0ddf0d0b0b0445fbac627396c1a68b9
Source dataset
uspto-grants-2012_05
Patent number
US08188284B2

Reaction notes

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