2-Amino-6-methylpyridine → HCID 68913943, compound

HRID 1931515Notes

Reaction equation

HRID 1931515 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH:13]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][C:20]=3[O:22][CH3:23])[CH2:15][CH2:14]1)[CH:6]=[CH:5]2.[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[N:26]=1>>[CH3:23][O:22][C:20]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:21]=1[CH:13]([NH:12][C:7]1[CH:6]=[CH:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([NH:24][C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[N:26]=4)[CH:3]=3)[N:8]=1)[CH2:14][CH2:15]2

Participants

3

Reactant 2

HCID 157652-Amino-6-methylpyridineHCID 68628631HCID 68628631, compound

Product 1

HCID 68913943HCID 68913943, compound

Procedure

The title compound, yellow foam, MS: m/e=397.3 (M+H+), was prepared in accordance with the general method of example 66 from rac-(6-bromo-quinolin-2-yl)-(7-methoxy-indan-1-yl)-amine (see example 91, step A) and commercially available 2-amino-6-methyl-pyridine.

Sources & evidence

ORD record
ord-fdad242f2ba9447b9adf2da32f8679b2
Source dataset
uspto-grants-2012_05
Patent number
US08188284B2

Reaction notes

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