2-Amino-6-(trifluoromethyl)pyridine → HCID 68918738, compound

HRID 1931516Notes

Reaction equation

HRID 1931516 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH:13]1[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[O:15][CH2:14]1)[CH:6]=[CH:5]2.[NH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[N:24]=1>>[O:15]1[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH:13]([NH:12][C:7]2[CH:6]=[CH:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([NH:22][C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:31])([F:30])[F:32])[N:24]=4)[CH:3]=3)[N:8]=2)[CH2:14]1

Participants

3

Reactant 2

HCID 8210242-Amino-6-(trifluoromethyl)pyridineHCID 68629632HCID 68629632, compound

Product 1

HCID 68918738HCID 68918738, compound

Procedure

The title compound, light yellow foam, MS: m/e=423.2 (M+H+), was prepared in accordance with the general method of example 66 from rac-(6-bromo-quinolin-2-yl)-(2,3-dihydro-benzofuran-3-yl)-amine (see example 96, step A) and commercially available 2-amino-6-trifluoromethyl-pyridine.

Sources & evidence

ORD record
ord-cb70f1e8ec9c4f7e88d83534230cde4c
Source dataset
uspto-grants-2012_05
Patent number
US08188284B2

Reaction notes

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