2-Amino-6-(trifluoromethyl)pyridine → HCID 68911855, compound

HRID 1931519Notes

Reaction equation

HRID 1931519 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH:13]1[C:21]3[C:16](=[CH:17][C:18]([F:22])=[CH:19][CH:20]=3)[CH2:15][CH2:14]1)[CH:6]=[CH:5]2.[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[N:25]=1>>[F:22][C:18]1[CH:17]=[C:16]2[C:21](=[CH:20][CH:19]=1)[CH:13]([NH:12][C:7]1[CH:6]=[CH:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([NH:23][C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:32])([F:31])[F:33])[N:25]=4)[CH:3]=3)[N:8]=1)[CH2:14][CH2:15]2

Participants

3

Reactant 2

HCID 8210242-Amino-6-(trifluoromethyl)pyridineHCID 68630098HCID 68630098, compound

Product 1

HCID 68911855HCID 68911855, compound

Procedure

The title compound, yellow foam, MS: m/e=439.2 (M+H+), was prepared in accordance with the general method of example 66 from rac-(6-bromo-quinolin-2-yl)-(5-fluoro-indan-1-yl)-amine (see example 102, step A) and commercially available 2-amino-6-trifluoromethyl-pyridine.

Sources & evidence

ORD record
ord-db6efe2fe21744f29b51fec35321587e
Source dataset
uspto-grants-2012_05
Patent number
US08188284B2

Reaction notes

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