2-Amino-6-methylpyridine → HCID 44217152, compound

HRID 1931525Notes

Reaction equation

HRID 1931525 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH:13]1[C:17]3[C:18]([O:22][CH3:23])=[CH:19][CH:20]=[CH:21][C:16]=3[O:15][CH2:14]1)[CH:6]=[CH:5]2.[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[N:26]=1>>[CH3:23][O:22][C:18]1[C:17]2[CH:13]([NH:12][C:7]3[CH:6]=[CH:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([NH:24][C:25]5[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[N:26]=5)[CH:3]=4)[N:8]=3)[CH2:14][O:15][C:16]=2[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 157652-Amino-6-methylpyridineHCID 68629261HCID 68629261, compound

Product 1

HCID 44217152HCID 44217152, compound

Procedure

The title compound, yellow foam, MS: m/e=399.2 (M+H+), was prepared in accordance with the general method of example 66 from rac-(6-bromo-quinolin-2-yl)-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-amine (see example 109, step C) and commercially available 2-amino-6-methyl-pyridine.

Sources & evidence

ORD record
ord-ec384862353244fc87660e809e4d936c
Source dataset
uspto-grants-2012_05
Patent number
US08188284B2

Reaction notes

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