反应详情

A solution of 2-fluoro-4-methanesulfonyl-1-methoxy-benzene (1.00 g, 4.9 mmol) in a mixture of 48% aqueous HBr (3 mL) and 33% HBr in acetic acid (1.5 mL) was heated at reflux for 20 h. The reaction mixture was cooled to room temperature and extracted with ethyl acetate. The organic layer was dried (sodium sulfate), filtered, evaporated and chromatographed, eluting with 30% ethyl acetate/hexanes, to give 2-fluoro-4-methanesulfonyl-phenol (800 mg, 86%) as a white solid. Mass spectrum (APCI) m/z M−H=189.

1. temperaturewas heated
2. temperatureat reflux for 20 h
3. extractionextracted with ethyl acetate
4. dry with materialThe organic layer was dried (sodium sulfate)
5. filtrationfiltered
6. customevaporated
7. customchromatographed
8. washeluting with 30% ethyl acetate/hexanes