反应详情

4-[4-(4-Tetrazol-2-yl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (16 mg, 19%) was prepared using the procedure described for the preparation of Example 41 by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19; 60 mg, 0.18 mmol) with 4-(2H-tetrazol-2-yl)phenol (ChemBridge Corporation, San Diego, Calif., USA; 29 mg, 0.18 mmol) in the presence of potassium carbonate (54 mg, 0.39 mmol).