HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 25145780, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-Iodopropane | HCID 33643 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | HCID 63585886 | HCID 63585886 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 25145780 | HCID 25145780 | — |
Reaction Steps
Preparation according to Example 8: 3-(3,5-difluorophenyl)pyrrolidin-3-ol (0.54 g, 2.7 mmol), acetonitrile (30 mL), sodium carbonate (0.38 g, 6.75 mmol), iodopropane (0.26 mL, 2.7 mmol). Yield: 0.22 g. The amine was converted to the fumaric acid salt: M.p. 136-137° C.; MS m/z (relative intensity, 70 eV) 241 (M+, 8), 213 (13), 212 (bp), 182 (34), 84 (60).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188301B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-09d92df9bf0345d3ab0659dc2304a1f2 |
| Source note | uspto-grants-2012_05 |