反应详情

Preparation according to Example 8: 3-(3,5-difluorophenyl)pyrrolidin-3-ol (0.54 g, 2.7 mmol), acetonitrile (30 mL), sodium carbonate (0.38 g, 6.75 mmol), iodopropane (0.26 mL, 2.7 mmol). Yield: 0.22 g. The amine was converted to the fumaric acid salt: M.p. 136-137° C.; MS m/z (relative intensity, 70 eV) 241 (M+, 8), 213 (13), 212 (bp), 182 (34), 84 (60).

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