反应详情

Preparation according to Preparation 18: Enantiomer E2 of 1-benzyl-3-(3,4-difluorophenyl)pyrrolidin-3-ol (0.835 g, 2.89 mmol), methanol (15 mL), palladium on carbon (165 mg), triethyl silane (6.7 g, 57.7 mmol). Reaction restart: Methanol (15 mL), palladium on carbon (165 mg), triethyl silane (6.7 g, 57.7 mmol). Purification on a Biotage Isolute SCX-3 SPE column (washed with methanol and eluted with methanol/triethylamine 4:1). Yield: 0.54 g. MS m/z (relative intensity, 70 eV) 199 (M+, 85), 141, (bp), 127 (58), 114 (53), 113 (98).

1. customPreparation
2. customaccording to Preparation 18
3. customReaction restart
4. customPurification
5. washon a Biotage Isolute SCX-3 SPE column (washed with methanol and eluted with methanol/triethylamine 4:1)