Triethylsilane → HCID 63585886, compound

HRID 1931884Notes

Reaction equation

HRID 1931884 reaction equation
C([N:8]1[CH2:12][CH2:11][C:10]([C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[CH:15]=2)([OH:13])[CH2:9]1)C1C=CC=CC=1.C([SiH](CC)CC)C>[Pd].CO>[F:21][C:16]1[CH:15]=[C:14]([C:10]2([OH:13])[CH2:11][CH2:12][NH:8][CH2:9]2)[CH:19]=[C:18]([F:20])[CH:17]=1

Participants

5

Reactant 2

HCID 12052TriethylsilaneHCID 19935801HCID 19935801, compound

Product 1

HCID 63585886HCID 63585886, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Preparation according to Preparation 18: (+)-1-benzyl-3-(3,5-difluorophenyl)pyrrolidin-3-ol (2.89 g, 10 mmol), methanol (20 mL), palladium on carbon (500 mg), triethyl silane (15.97 mL, 100 mmol). Yield 0.92 g. MS m/z (relative intensity, 70 eV) 199 (M+, bp), 141, (61), 127 (72), 114 (57), 113 (84).

Workup

  1. customPreparation
  2. customaccording to Preparation 18

Sources & evidence

ORD record
ord-cda991830a1144ff9fd7e7ccc6a00804
Source dataset
uspto-grants-2012_05
Patent number
US08188301B2

Reaction notes

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