反应详情

Preparation according to Preparation 2: tert-Butyl 3-(3-Chloro-5-fluorophenyl)-3-hydroxypyrrolidin-1-carboxylate (1.6 g, 5.08 mmol), dichloromethane (3 mL) and trifluoroacetic acid (3 mL). Stirred for 4 h. Purification on a Biotage (solute SCX-3 SPE column (washed with methanol and eluted with methanol/triethylamine, 4:1) and by HPLC on Waters OBD C18, 5 μm (MeOH/33 mM NH3, 20:80 to 100:0). Yield: 1.1 g. MS m/z (rel. intensity, 70 eV) 215 (M+, bp), 129 (65), 109 (52), 157 (46), 95 (44).

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4. washsolute SCX-3 SPE column (washed with methanol and eluted with methanol/triethylamine, 4:1)