反应详情

Preparation according to preparation 4: (−)-1-benzyl-3-(2,3-difluorophenyl)pyrrolidin-3-ol (5.5 g, 19 mmol), ammonium formiate (3 g, 48 mmol), ethanol (100 mL) and palladium on carbon (300 mg). Refluxed for 35 min. Dichloromethane/tert-butylmethyleter (1:1, 100 mL) was added and the mixture was filtrated through celite, the filtrate was evaporated to give the title compound (4.5 g). MS m/z (relative intensity, 70 eV) 199 (M+100) 141 (82), 113 (61), 124 (59), 63 (45).

1. customPreparation
2. customaccording to preparation 4
3. temperatureRefluxed for 35 min
4. filtrationthe mixture was filtrated through celite
5. customthe filtrate was evaporated