Acetyl chloride → HCID 18613788, compound

HRID 1932304Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[C:11](Cl)(=O)[CH3:12]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8][CH:11]2[CH3:12])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 674302-(4-Chlorophenyl)ethylamine

Product 1

HCID 18613788HCID 18613788, compound

Procedure

In accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21, except for using 4-chlorophenethylamine and acetyl chloride, 7-chloro-1-methyl-1,2,3,4-tetrahydroisoquinoline was obtained. In accordance with the same procedures as in Preparation 20, the titled compound was obtained as pale yellow oil. (Yield: 67%) The product was used in the subsequent step without further purification.

Workup

customIn accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21

Sources & evidence

ORD record: ord-475161a1d9c449d988b83a46df4d3b1c
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188114B2

Reaction notes

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