Phenethylamine → HCID 3798338, compound

HRID 1932309Notes

Reaction equation

[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:10](Cl)(=O)[CH2:11][CH3:12]>>[CH2:11]([CH:12]1[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2][CH2:1][NH:9]1)[CH3:10]

Participants

Reactant 2

HCID 1001Phenethylamine

HCID 62324Propionyl chloride

Product 1

HCID 3798338HCID 3798338, compound

Procedure

In accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21, except for using phenethylamine and propionyl chloride, 1-ethyl-1,2,3,4-tetrahydroisoquinoline was obtained. In accordance with the same procedures as in Preparation 20, the titled compound was obtained as pale yellow oil. (Yield: 78%) The product was used in the subsequent step without further purification.

Workup

customIn accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21

Sources & evidence

ORD record: ord-6805e953ce4c4b42abb502ac7dc7d538
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188114B2

Reaction notes

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