Ethyl ketone → HCID 86615251, compound

HRID 1932311Notes

Reaction equation

HRID 1932311 reaction equation
[CH3:1][CH2:2][C:3](=O)[CH2:4][CH3:5].[Cl:7][C:8]1[C:13]([NH:14][NH2:15])=[CH:12][CH:11]=[CH:10][N:9]=1>C(O)C>[Cl:7][C:8]1[C:13]([NH:14][N:15]=[C:3]([CH2:4][CH3:5])[CH2:2][CH3:1])=[CH:12][CH:11]=[CH:10][N:9]=1

Participants

4

Reactant 2

HCID 7288Ethyl ketoneHCID 140403472-Chloro-3-hydrazinylpyridine

Product 1

HCID 86615251HCID 86615251, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Pentanone (1.1 ml, 10.4 mmol) was added to a solution of (2-chloropyridin-3-yl)-hydrazine (1 g, 6.96 mmol) prepared in Step 1 in ethanol (35 ml). The reaction mixture was refluxed overnight. The reaction mixture was concentrated under reduced pressure and then purified with silica gel column chromatography to give 1.3 g of the titled compound as pale yellow oil. (Yield: 88%).

Workup

  1. temperatureThe reaction mixture was refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. custompurified with silica gel column chromatography

Sources & evidence

ORD record
ord-d3a66a2d7cd84e1195712566caccc1c5
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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