P-Cresol → 2-(4-Methylphenoxymethyl)-3-nitropyridine

HRID 1932314Notes

Reaction equation

HRID 1932314 reaction equation
Br[CH2:2][C:3]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1.[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1>>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:2][C:3]2[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 2879P-CresolHCID 218311782-(Bromomethyl)-3-nitropyridine

Product 1

HCID 671414232-(4-Methylphenoxymethyl)-3-nitropyridineYield 85%

Procedure

In accordance with the same procedures as in Step 3 of Preparation 1, except for using 2-bromomethyl-3-nitropyridine prepared in Step 2 of Preparation 1 and 4-methylphenol, the titled compound was obtained as yellow solid. (Yield: 85%)

Workup

  1. customIn accordance with the same procedures as in Step 3 of Preparation 1

Sources & evidence

ORD record
ord-cdf87855d0ff42498cc0a58fe177b8d2
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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