4-Chlorophenol → 2-(4-Chlorophenoxymethyl)-3-nitropyridine

HRID 1932316Notes

Reaction equation

Br[CH2:2][C:3]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1>>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:2][C:3]2[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=2)=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 46844-Chlorophenol

HCID 218311782-(Bromomethyl)-3-nitropyridine

Product 1

HCID 671428772-(4-Chlorophenoxymethyl)-3-nitropyridineYield 90%

Procedure

In accordance with the same procedures as in Step 3 of Preparation 1, except for using 2-bromomethyl-3-nitropyridine prepared in Step 2 of Preparation 1 and 4-chlorophenol, the titled compound was obtained as yellow solid. (Yield: 90%)

Workup

customIn accordance with the same procedures as in Step 3 of Preparation 1

Sources & evidence

ORD record: ord-da96f5d7d2b24f129a688613d1c1b9dd
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188114B2

Reaction notes

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