2-Chlorophenol → 2-(2-Chlorophenoxymethyl)-3-nitropyridine

HRID 1932318Notes

Reaction equation

Br[CH2:2][C:3]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[OH:19]>>[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH2:2][C:3]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

Reactant 2

HCID 72452-Chlorophenol

HCID 218311782-(Bromomethyl)-3-nitropyridine

Product 1

HCID 671415762-(2-Chlorophenoxymethyl)-3-nitropyridineYield 85%

Procedure

In accordance with the same procedures as in Step 3 of Preparation 1, except for using 2-bromomethyl-3-nitropyridine prepared in Step 2 of Preparation 1 and 2-chlorophenol, the titled compound was obtained as yellow oil. (Yield: 85%)

Workup

customIn accordance with the same procedures as in Step 3 of Preparation 1

Sources & evidence

ORD record: ord-2232a2d46b924bfe80a80924af242501
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188114B2

Reaction notes

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