4-Fluoro-N-methylaniline → (4-Fluorophenyl)-methyl-(3-nitropyridin-2-ylmethyl)-amine

HRID 1932323Notes

Reaction equation

HRID 1932323 reaction equation
Br[CH2:2][C:3]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][CH3:20])=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]([CH3:20])[CH2:2][C:3]2[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 680244-Fluoro-N-methylanilineHCID 218311782-(Bromomethyl)-3-nitropyridine

Product 1

HCID 67141956(4-Fluorophenyl)-methyl-(3-nitropyridin-2-ylmethyl)-amineYield 80%

Procedure

In accordance with the same procedures as in Step 1 of Preparation 2, except for using 2-bromomethyl-3-nitropyridine prepared in Step 2 of Preparation 1 and (4-fluorophenyl)-methylamine, the titled compound was obtained as yellow solid. (Yield: 80%)

Workup

  1. customIn accordance with the same procedures as in Step 1 of Preparation 2

Sources & evidence

ORD record
ord-b6ea144c535a40659c4a51d37a54c6f8
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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