Benzyl Bromide → 1-benzyl-7-chloro-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine

HRID 1932332Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[NH:8][C:7]=12.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([N:8]1[C:7]2=[C:2]([Cl:1])[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]1[CH3:12])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 116369277-Chloro-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine

Product 1

HCID 115652711-benzyl-7-chloro-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridineYield 42%

Procedure

In accordance with the same procedures as in Step 2 of Example 198, except for using 7-chloro-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine prepared in Step 1 of Example 198 and benzyl bromide, the titled compound was obtained as a white solid. (Yield: 42%)

Sources & evidence

ORD record: ord-8e8e1f1ecac24601a7c2b319ec5d38bf
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188114B2

Reaction notes

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