Sodium Bicarbonate → HCID 67141802, compound

HRID 1932368Notes

Reaction equation

HRID 1932368 reaction equation
[CH2:1]([N:8]1[C:12]2=[C:13]([N:17]3[CH2:26][CH2:25][C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:18]3)[N:14]=[CH:15][CH:16]=[C:11]2[CH:10]=[C:9]1[CH3:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28].[CH2:29]([N:36]1[C:40]2=C(N3CCC4C(=CC=CC=4)C3)N=CC=C2C=[C:37]1C)C1C=CC=CC=1.C(=O)(O)[O-].[Na+]>>[ClH:28].[CH2:1]([N:8]1[C:12]2=[C:13]([N:17]3[CH2:26][CH2:25][C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:18]3)[N:14]=[CH:15][CH:16]=[C:11]2[C:10]([CH2:29][N:36]([CH3:40])[CH3:37])=[C:9]1[CH3:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 516892Sodium BicarbonateHCID 67143083HCID 67143083, compoundHCID 67143097HCID 67143097, compound

Product 1

HCID 67141802HCID 67141802, compoundYield 72%

Procedure

In accordance with the same procedures as in Example 619, except for using 2-(1-benzyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline obtained by treating the compound prepared in Example 614 with a saturated sodium bicarbonate solution, the titled compound was obtained as a white solid. (Yield: 72%)

Workup

  1. customobtained

Sources & evidence

ORD record
ord-734bdd78d3c04e2d862cf5e899b593ce
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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