Sodium Bicarbonate → HCID 67141305, compound

HRID 1932398Notes

Reaction equation

HRID 1932398 reaction equation
[CH2:1]([N:8]1[C:12]2=[C:13]([N:21]3[CH2:30][CH2:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22]3)[N:14]=[C:15]([C:17](=[O:20])[CH2:18][CH3:19])[CH:16]=[C:11]2[C:10]([CH3:31])=[C:9]1[CH3:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33].C(N1C2=C(N3CCC4C(=CC=CC=4)C3)N=C(C(=O)CC)C=C2C(C)=C1C)C1C=CC=CC=1.C(=O)(O)[O-].[Na+]>>[ClH:33].[CH2:1]([N:8]1[C:12]2=[C:13]([N:21]3[CH2:30][CH2:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22]3)[N:14]=[C:15]([CH:17]([OH:20])[CH2:18][CH3:19])[CH:16]=[C:11]2[C:10]([CH3:31])=[C:9]1[CH3:32])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 516892Sodium BicarbonateHCID 67141935HCID 67141935, compoundHCID 67141936HCID 67141936, compound

Product 1

HCID 67141305HCID 67141305, compoundYield 95%

Procedure

In accordance with the same procedures as in Example 860, except for using 1-[1-benzyl-7-(3,4-dihydro-1H-isoquinolin-2-yl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-5-yl]-propan-1-one obtained by treating the compound prepared in Example 856 with a saturated sodium bicarbonate solution, the titled compound was obtained as a white solid. (Yield: 95%)

Workup

  1. customobtained

Sources & evidence

ORD record
ord-7d45a049011c46d09bbc8656dee4854d
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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