Ethyl 3-[4-(4-nitrophenoxy)phenyl]propionate → HCID 68523825, compound

HRID 1932453Notes

Reaction equation

HRID 1932453 reaction equation
[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=2)=[CH:22][CH:23]=1

Participants

4

Reactant 1

HCID 68524232Ethyl 3-[4-(4-nitrophenoxy)phenyl]propionate

Product 1

HCID 68523825HCID 68523825, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a suspension of 5% palladium-carbon (0.50 g) in ethanol (50 mL) was added ethyl 3-[4-(4-nitrophenoxy)phenyl]propionate (5.00 g, 15.9 mmol), and the resulting solution was subjected to catalytic reduction at atmospheric pressure and at room temperature. Once the absorption of hydrogen had stopped, the catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure, to thereby yield 4.52 g of the title compound.

Workup

  1. customwas subjected to catalytic reduction at atmospheric pressure and at room temperature
  2. customOnce the absorption of hydrogen
  3. customthe catalyst was removed by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-320e125b223041b799f4d38f39c92b39
Source dataset
uspto-grants-2012_05
Patent number
US08188277B2

Reaction notes

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