Water → HCID 86616535, compound

HRID 1932498Notes

Reaction equation

HRID 1932498 reaction equation
C1(O[C:8](=[O:27])[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:18]=3[F:26])=[CH:12][CH:11]=2)C=CC=CC=1.[CH2:28]([N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1)[C:29]1[CH:37]=[CH:36][C:35]2[O:34][CH2:33][O:32][C:31]=2[CH:30]=1.O>CN(C=O)C>[F:26][C:18]1[CH:19]=[C:20]([N+:23]([O-:25])=[O:24])[CH:21]=[CH:22][C:17]=1[O:16][C:13]1[CH:12]=[CH:11][C:10]([NH:9][C:8]([N:41]2[CH2:42][CH2:43][N:38]([CH2:28][C:29]3[CH:37]=[CH:36][C:35]4[O:34][CH2:33][O:32][C:31]=4[CH:30]=3)[CH2:39][CH2:40]2)=[O:27])=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 962WaterHCID 944261-PiperonylpiperazineHCID 68527058HCID 68527058, compound

Product 1

HCID 86616535HCID 86616535, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of [4-(2-fluoro-4-nitrophenoxy)phenyl]carbamate phenyl ester (0.700 g, 1.90 mmol) in DMF (15 mL) was added 1-piperonylpiperazine (0.460 g, 2.09 mmol), and the resulting solution was stirred for 2 hours at room temperature. water was added to the resulting reaction solution, and extracted with ethyl acetate. The ethyl acetate layer was washed with brine. The ethyl acetate layer was dried over anhydrous sodium sulfate, and evaporated, to thereby yield 0.939 g of the title compound.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with brine
  3. dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-bae147069c8d4fc3bcd08931d6726758
Source dataset
uspto-grants-2012_05
Patent number
US08188277B2

Reaction notes

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