Toluene → 2-((2-Chloro-6-fluorophenyl)amino)-N-(2-fluoro-4-methylphenyl)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide

HRID 193303Notes

Reaction equation

HRID 193303 reaction equation
[CH3:38][Al:39]([CH3:40])[CH3:41].[CH3:42][c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1.[Cl:1][c:2]1[c:3]([NH:9][c:10]2[n:11][c:12]3[c:13]([n:14]2[CH3:15])[c:16]2[c:20]([c:21]([C:23]([O:25][CH3:24])=[O:26])[cH:22]3)[O:19][C:18]([CH3:27])([CH3:28])[CH2:17]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1.[F:29][c:30]1[c:31]([NH2:32])[cH:33][cH:34][c:35]([CH3:37])[cH:36]1>>[Cl:1][c:2]1[c:3]([NH:9][c:10]2[n:11][c:12]3[c:13]([n:14]2[CH3:15])[c:16]2[c:20]([c:21]([C:23](=[O:25])[NH:32][c:31]4[c:30]([F:29])[cH:36][c:35]([CH3:37])[cH:34][cH:33]4)[cH:22]3)[O:19][C:18]([CH3:27])([CH3:28])[CH2:17]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 679842-Fluoro-4-methylanilineHCID 16682925TrimethylaluminumHCID 67503529methyl 2-((2-chloro-6-fluorophenyl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

Product 1

HCID 569711162-((2-Chloro-6-fluorophenyl)amino)-N-(2-fluoro-4-methylphenyl)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide

Sources & evidence

ORD record
ord-8eae3c78255f484c8717db1224254665
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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