反应详情

温度

112.5 °C

Commercially available (−)-cocaine (Sigma Chemical Co.) was dissolved in 1.25 M HCl (1 g cocaine/12 ml). The mixture was allowed to stir for 16 hours at 110-115° C. (gentle reflux). After cooling to room temperature, the mixture was thoroughly extracted with ether to remove the benzoic acid by-product. The acidic aqueous layer was evaporated on a rotary evaporator under high vacuum and then the residue was redissolved in water and lyophilized to afford a white solid that required no further purification (92% yield).

1. temperature(gentle reflux)
2. temperatureAfter cooling to room temperature
3. extractionthe mixture was thoroughly extracted with ether
4. customto remove the benzoic acid by-product
5. customThe acidic aqueous layer was evaporated on a rotary evaporator under high vacuum
6. dissolutionthe residue was redissolved in water
7. customto afford a white solid that
8. customno further purification (92% yield)