Water → Ethanol, 2-(ethylphenylamino)-, 1-acetate

HRID 1934295Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1934295
[CH2:1]([N:3]([CH2:10][CH2:11][OH:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2].C(N(CC)CC)C.[C:20](Cl)(=[O:22])[CH3:21].O>CC(C)=O>[C:20]([O:12][CH2:11][CH2:10][N:3]([CH2:1][CH3:2])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)(=[O:22])[CH3:21]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 623382-(N-ethylanilino)ethanol

Produkt 1

HCID 113382Ethanol, 2-(ethylphenylamino)-, 1-acetateAusbeute 99,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

51.8 g of 2-(N-ethylanilino)ethanol and 31.7 g of triethylamine were dissolved in 300 ml of acetone. To this were slowly added 25 g of acetyl chloride while cooling the reaction solution with ice water, and this was caused to react for 6 hours at room temperature while stirring. 200 ml of water were poured in. An organic layer was extracted with ethyl acetate and dried with sodium sulfate. Then the solvent was boiled off under reduced pressure to yield 64.9 g of 2-(N-ethylanilino)ethyl acetate.

Aufarbeitung

  1. customto react for 6 hours at room temperature
  2. extractionAn organic layer was extracted with ethyl acetate
  3. dry with materialdried with sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-e21285f2e40447ec877ede9ed0a0a5c2
Quelldatensatz
uspto-grants-2002_05
Patentnummer
US06383714B1

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