HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodopropane → Diethyl 4-(ethylpropylamino)benzylacetamidomalonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodopropane | HCID 33643 | — |
| Reactant | 1,5-Diazabicyclo(4.3.0)non-5-ene | HCID 76349 | — |
| Reactant | Diethyl 4-ethylaminobenzylacetamidomalonate | HCID 54294942 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Diethyl 4-(ethylpropylamino)benzylacetamidomalonate | HCID 53944907 | — |
Reaction Steps
Working as in Example F, but starting with 10 g of diethyl 4-ethylaminobenzylacetamidomalonate, 5.6 ml of 1-iodopropane and 7.2 ml of 1,5-diazabicyclo-[4.3.0] non-5-ene in 70 ml of tetrahydrofuran, and after reacting for 36 hours followed by purification by flash chromatography (eluent: 97/3 CH2Cl2/MeOH by volume), 2.8 g of a solid are obtained, which solid is recrystallized from 26 ml of cyclohexane. 2.9 g of diethyl 4-(ethylpropylamino)benzylacetamidomalonate are thus obtained in the form of a white solid melting at 84-86° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384014B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-4f8b4f3358784c939681f362f1a181e5 |
| Source note | uspto-grants-2002_05 |