反应详情

Working as in Example F, but starting with 10 g of diethyl 4-ethylaminobenzylacetamidomalonate, 5.6 ml of 1-iodopropane and 7.2 ml of 1,5-diazabicyclo-[4.3.0] non-5-ene in 70 ml of tetrahydrofuran, and after reacting for 36 hours followed by purification by flash chromatography (eluent: 97/3 CH2Cl2/MeOH by volume), 2.8 g of a solid are obtained, which solid is recrystallized from 26 ml of cyclohexane. 2.9 g of diethyl 4-(ethylpropylamino)benzylacetamidomalonate are thus obtained in the form of a white solid melting at 84-86° C.

1. customfollowed by purification by flash chromatography (eluent: 97/3 CH2Cl2/MeOH by volume), 2.8 g of a solid
2. customare obtained
3. customwhich solid is recrystallized from 26 ml of cyclohexane