Sodium Hydroxide → HCID 10220455, compound

HRID 1934353Notes

Reaction equation

HRID 1934353 reaction equation
C[O:2][C:3]([C:5]([NH:8][C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])([CH3:7])[CH3:6])=[O:4].[OH-].[Na+]>CO>[C:3]([C:5]([NH:8][C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])([CH3:7])[CH3:6])([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10199015HCID 10199015, compound

Product 1

HCID 10220455HCID 10220455, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-(1-methoxycarbonyl-1-methylethyl)-2,4-difluorobenzamide obtained in Example 30 (1.51 g, 5.9 mmol) in methanol (10 ml) was added 4N aqueous NaOH (10 ml), and stirred at room temperature for 30 min. The methanol was evaporated and the resulting mixture was acidified with 4N hydrochloric acid and extracted with ethyl acetate. The extract was dried over Na2SO4 and the solvent was evaporated under a reduced pressure to give the title compound (1.42 g; 99%).

Workup

  1. customThe methanol was evaporated
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract was dried over Na2SO4
  4. customthe solvent was evaporated under a reduced pressure

Sources & evidence

ORD record
ord-af9670610c2346d48c16b417bae8b983
Source dataset
uspto-grants-2002_05
Patent number
US06384033B1

Reaction notes

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