Sodium Hydroxide → HCID 10220455, compound

Participants

Reaction Steps

To a solution of N-(1-methoxycarbonyl-1-methylethyl)-2,4-difluorobenzamide obtained in Example 30 (1.51 g, 5.9 mmol) in methanol (10 ml) was added 4N aqueous NaOH (10 ml), and stirred at room temperature for 30 min. The methanol was evaporated and the resulting mixture was acidified with 4N hydrochloric acid and extracted with ethyl acetate. The extract was dried over Na2SO4 and the solvent was evaporated under a reduced pressure to give the title compound (1.42 g; 99%).

Provenance & Evidence