反应详情

To water (100 ml) were added 5-fluoro-2-methylpyridine (J. Med. Chem., 32, 1970(1989): 2.2 g, 20 mmol) and potassium permanganate (19.1 g, 120 mmol), and heated under reflux for 4 hours. The reaction mixture was filtrated and the filtrate was concentrated, acidified with KHSO4, extracted with ethyl acetate and the extract was dried over Na2SO4. The sol vent was evaporated to give the title compound (0.80 g; 28%).

1. temperatureheated
2. temperatureunder reflux for 4 hours
3. filtrationThe reaction mixture was filtrated
4. concentrationthe filtrate was concentrated
5. extractionextracted with ethyl acetate
6. dry with materialthe extract was dried over Na2SO4
7. customThe sol vent was evaporated