HCID 18738154, compound → HCID 18738153, compound

HRID 1934377Notes

Reaction equation

HRID 1934377 reaction equation
[N:1]([CH2:4][C@H:5]([NH:11][C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH2:4][C@H:5]([NH:11][C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 1

HCID 18738154HCID 18738154, compound

Product 1

HCID 18738153HCID 18738153, compoundYield 79.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 3-azido-2(S)-(benzoylamino)propionate (0.35 g) and 10% Pd—C (0.07 g) in ethanol (4 ml) was hydrogenated at an atmospheric pressure for 2 hours. After the catalyst was removed by filtration, the filtrate was concentrated in vacuo to give ethyl 3-amino-2(S)-(benzoylamino)propionate (0.25 g).

Workup

  1. customAfter the catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-30c5cb2d7f9c42d28be00c0e8709f04b
Source dataset
uspto-grants-2002_05
Patent number
US06384028B1

Reaction notes

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