Hydrochloric Acid → HCID 86758021, compound

HRID 1934380Notes

Reaction equation

HRID 1934380 reaction equation
[Si]([N:8]1[C@H:11]([C:12]2[O:16][N:15]=[C:14]([CH3:17])[CH:13]=2)[CH2:10][C:9]1=[O:18])(C(C)(C)C)(C)C.[ClH:19].[CH3:20][CH2:21][OH:22]>>[ClH:19].[CH2:21]([O:22][C:9](=[O:18])[CH2:10][C@@H:11]([C:12]1[O:16][N:15]=[C:14]([CH3:17])[CH:13]=1)[NH2:8])[CH3:20]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702Ethanol2×HCID 54382464HCID 54382464, compound

Product 1

HCID 86758021HCID 86758021, compound

Procedure

A solution of 1-tert-butyldimethylsilyl-4(S)-(3-methyl-5-isoxazolyl)-2-azetidinone (0.9 g) in EtOH (10 ml) was added HCl (16.9 mmol)/EtOH (4.2 ml) at room temperature at 0° C. The reaction mixture was stirred at room temperature for 2 hours, then evaporated in vacuo. The residue was recrystallized from diethyl ether to give 3(S)-(3-methyl-5-isoxazolyl)-β-alanine ethyl ester hydrochloride (0.67 g) as a white solid.

Workup

  1. customevaporated in vacuo
  2. customThe residue was recrystallized from diethyl ether

Sources & evidence

ORD record
ord-23968f9be3c54f409f602087c23e49ef
Source dataset
uspto-grants-2002_05
Patent number
US06384028B1

Reaction notes

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