Sodium Bicarbonate → HCID 54396927, compound

HRID 1934400Notes

Reaction equation

HRID 1934400 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][C:10]([N:12]2[CH2:17][CH2:16][CH2:15][C@@H:14]([C:18]([NH:20][C:21]3[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=3)[C:24]([OH:26])=[O:25])=[O:19])[CH2:13]2)=[O:11])[CH2:4][CH2:3]1.C([O-])(O)=O.[Na+]>>[NH:2]1[CH2:3][CH2:4][CH:5]([CH2:8][CH2:9][C:10]([N:12]2[CH2:17][CH2:16][CH2:15][C@@H:14]([C:18]([NH:20][C:21]3[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=3)[C:24]([OH:26])=[O:25])=[O:19])[CH2:13]2)=[O:11])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 70094587HCID 70094587, compound

Product 1

HCID 54396927HCID 54396927, compoundYield 80.1%

Procedure

A solution of 3-[(R)-1-[3-(4-piperidyl)propanoyl]-3-piperidylcarbonyl]aminobenzoic acid hydrochloride (1 g) was neutralized by saturated aqueous NaHCO3, desalted by using the resin of HP-20 eluting with H2O: isopropanol=(1:1), then freeze-dried to give 3-[(R)-1-[3-(4-piperidyl)propanoyl]-3-piperidylcarbonyl]aminobenzoic acid (732 mg 80.1%).

Workup

  1. washeluting with H2O
  2. dry with materialisopropanol=(1:1), then freeze-dried

Sources & evidence

ORD record
ord-f4f450f5030c4be9a6cc05869d115603
Source dataset
uspto-grants-2002_05
Patent number
US06384028B1

Reaction notes

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