Hydrochloric Acid → HCID 178435420, compound

HRID 1934413Notes

Reaction equation

HRID 1934413 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([CH2:9][C:10]2([CH2:15][CH3:16])OCCO2)=[C:4]([NH2:17])[N:3]=1.Cl>>[CH3:1][C:2]1[NH:3][C:4]2[NH:17][C:10]([CH2:15][CH3:16])=[CH:9][C:5]=2[C:6](=[O:8])[N:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178435405HCID 178435405, compound

Product 1

HCID 178435420HCID 178435420, compound

Procedure

The 2-methyl-6-amino-5-(2-ethyl-1,3-dioxolan-2-ylmethyl)-4-pyrimidinol (5.50 g, 22.9 mmol) was combined with 172 mL of 0.2 M HCl and stirred at ambient temperature for 18 hours. The solids were collected by filtration, washed with 40 mL of water and dried in vacuo (40° C., 10 torr) to 3.70 g (91%) of 1,7-dihydro-2-methyl-6-ethyl-4H-pyrrolo[2,3-d]pyrimidin-4-one as a tan solid. nmr (500 MHz, dmso-d6) δ1.18 (t, J=7.5 Hz, 3H), 2.26 (s, 3H), 2.57 (q, J=7.5 Hz, 2H), 6.04 (s, 1H), 11.42 (s, 1H), 11.57 (s, 1H)

Workup

  1. filtrationThe solids were collected by filtration
  2. washwashed with 40 mL of water
  3. dry with materialdried in vacuo (40° C., 10 torr) to 3.70 g (91%) of 1,7-dihydro-2-methyl-6-ethyl-4H-pyrrolo[2,3-d]pyrimidin-4-one as a tan solid

Sources & evidence

ORD record
ord-2206d26631644abc9df367b04305a110
Source dataset
uspto-grants-2002_05
Patent number
US06384041B1

Reaction notes

Loading…