1,2-Cyclopentanedicarboxylic acid, 3-oxo-, 1,2-dimethyl ester → HCID 10878160, compound

HRID 1934570Notes

Reaction equation

HRID 1934570 reaction equation
COC([CH:5]1[CH:9]([C:10]([O:12][CH3:13])=[O:11])[CH2:8][CH2:7][C:6]1=[O:14])=O.OCC1CC(CO)C[C:18]1=[O:24].[OH:25][CH2:26]C1C(CO)CCC1=O>>[CH3:26][O:25][C:18]([CH:7]1[CH2:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[CH2:5][C:6]1=[O:14])=[O:24]

Participants

4

Reactant 3

HCID 133238591,2-Cyclopentanedicarboxylic acid, 3-oxo-, 1,2-dimethyl esterHCID 18738774HCID 18738774, compoundHCID 18738795HCID 18738795, compound

Product 1

HCID 10878160HCID 10878160, compound

Procedure

2,4-Bis(methoxycarbonyl)cyclopentanone (Compound 1A-A) is prepared as a mixture with 2,3-bis(methoxycarbonyl)cyclopentanone (Compound 1-Aa), e.g., by the process described in J. Org. Chem., 47, 2379 (1982). By converting the mixture into 2,4-bis(hydroxymethyl)cyclopentanone and 2,3-bis(hydroxymethyl)cyclopentanone, the two compounds can be separated from each other by silica gel column chromatography.

Workup

  1. customthe two compounds can be separated from each other by silica gel column chromatography

Sources & evidence

ORD record
ord-2912e89d10264af2b94bf0e61ffac773
Source dataset
uspto-grants-2002_05
Patent number
US06384063B1

Reaction notes

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