Ethanolamine → N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

HRID 1934639Notes

Reaction equation

HRID 1934639 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[OH:13][CH2:12][CH2:14][NH:15][S:7]([C:4]1[CH:5]=[CH:6][C:1]([CH3:11])=[CH:2][CH:3]=1)(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 73974-Toluenesulfonyl chloride

Product 1

HCID 1895595N-(2-hydroxyethyl)-4-methylbenzenesulfonamideYield 94.8%

Procedure

The preparation is carried out as in Example 1(a) but this time 381.3 g of p-toluenesulphonyl chloride (2 mol) and 128.3 g of ethanolamine (2.1 mol) are used for the reaction. The amount obtained is 400.8 g, i.e. a yield of 94.8%.

Workup

  1. customThe amount obtained

Sources & evidence

ORD record
ord-44ea4a17a97346f8ac89b845c9574f44
Source dataset
uspto-grants-2002_05
Patent number
US06384115B1

Reaction notes

Loading…