Ethyl Acetate → HCID 22467108, compound

HRID 1934758Notes

Reaction equation

HRID 1934758 reaction equation
[C:1]([CH2:4][CH:5]1[C:9](=[O:10])[N:8]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7]2([CH2:23][CH2:22][N:21]([C:24](=[O:30])[CH2:25][CH2:26][C:27]([OH:29])=[O:28])[CH2:20][CH2:19]2)[S:6]1)([OH:3])=[O:2].[OH-].[Na+:32].C(OCC)(=O)C>C(O)C>[C:1]([CH2:4][CH:5]1[C:9](=[O:10])[N:8]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7]2([CH2:23][CH2:22][N:21]([C:24](=[O:30])[CH2:25][CH2:26][C:27]([O-:29])=[O:28])[CH2:20][CH2:19]2)[S:6]1)([OH:3])=[O:2].[Na+:32].[Na+:32].[C:1]([CH2:4][CH:5]1[C:9](=[O:10])[N:8]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7]2([CH2:23][CH2:22][N:21]([C:24](=[O:30])[CH2:25][CH2:26][C:27]([O-:29])=[O:28])[CH2:20][CH2:19]2)[S:6]1)([OH:3])=[O:2]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 22467109HCID 22467109, compound

Product 1

HCID 22467108HCID 22467108, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 1.4 ml of ethanol was dissolved 0.31 g of 4-[2-(carboxymethyl)-3-oxo-4-phenethyl-1-thia-4,8-diazaspiro[4.5]decan-8-yl]-4-oxobutanoic acid. After adding 1.36 ml of 1 mol/L aqueous solution of sodium hydroxide at 0-5° C., the resulting mixture was stirred at ambient temperature for 5 hours. The reaction mixture was poured into a mixture of ice water and ethyl acetate, and the aqueous layer was separated. The aqueous layer thus obtained was concentrated under reduce pressure to obtain 0.32 g of disodium 4-[2-(carboxymethyl)-3-oxo-4-phenethyl-1-thia-4,8-diazaspiro[4.5]decan-8-yl]-4-oxobutanoate as a colorless solid product.

Workup

  1. customthe aqueous layer was separated
  2. customThe aqueous layer thus obtained
  3. concentrationwas concentrated

Sources & evidence

ORD record
ord-e081f59b7cfb4956924ec6b9e19e7183
Source dataset
uspto-grants-2002_05
Patent number
US06384065B1

Reaction notes

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