HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 2-Chloro-5,6,7,8-tetrahydroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline | HCID 12602864 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 2-Chloro-5,6,7,8-tetrahydroquinazoline | HCID 12933876 | — |
Reaction Steps
2, 4-Dichloro-5,6,7,8-tetrahydroquinazoline (4 g) is dissolved in 50 mL of methylene chloride and the resulting solution covered with 9% NH4OH in saturated brine. Zinc (4 g) is added and the resulting mixture gently refluxed overnight. After filtration through celite, the organic layer is washed with water, dried and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384224B2 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-c1321509788c4a2fb398668b59901f1e |
| Source note | uspto-grants-2002_05 |