Diphenylphosphinic chloride → HCID 15434705, compound

HRID 1934863Notes

Reaction equation

HRID 1934863 reaction equation
[CH3:1][C:2]1[C:6]([CH3:7])=[C:5]([NH2:8])[O:4][N:3]=1.[C:9]1([P:15](Cl)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>N1C=CC=CC=1>[CH3:1][C:2]1[C:6]([CH3:7])=[C:5]([NH:8][P:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:16])[O:4][N:3]=1

Participants

4

Reactant 2

HCID 73910Diphenylphosphinic chlorideHCID 883175-Amino-3,4-dimethylisoxazole

Product 1

HCID 15434705HCID 15434705, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-(3,4-dimethyl-5-isoxazolyl)diphenyl phosphinic amide was prepared by the method of Example 1 with 3,4-dimethyl-5-amino isoxazole (0.22 g, 2.0 mmol), diphenyl phosphinic chloride (0.6 ml, 3.0 mmol) and pyridine (5 ml). Flash chromatography (5% methanol/chloroform) followed by recrystallization from ethyl acetate and hexanes provided 0.38 g (61%) of white crystals, m.p. 167-170° C.

Workup

  1. customFlash chromatography (5% methanol/chloroform) followed by recrystallization from ethyl acetate and hexanes

Sources & evidence

ORD record
ord-fdf41f7785294986b86f43c79f7e060c
Source dataset
uspto-grants-2002_05
Patent number
US06384261B1

Reaction notes

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