反应详情

温度

0 °C

A mixture of 4.03 g of 4-[(3-bromophenyl)amino]-6,7-dimethoxy-3-quinolinecarboxylic acid, 3.24 g of carbonyldiimiazole, and 100 ml of dimethylformamide was heated at 55 for 30 m, cooled to 0° C., and saturated with ammonia gas. After warming to 25 the resulting solution was stirred for 45 m, heated at 50, and evaporated to remove dimethylformamide. The residue was stirred with water, and the resulting solid was filtered, washed with water, and dried. Recrystallization from acetone gave a grey solid, mp 239-242° C.

1. temperaturewas heated at 55 for 30 m
2. temperatureAfter warming to 25 the resulting solution
3. temperatureheated at 50
4. customevaporated
5. customto remove dimethylformamide
6. stirringThe residue was stirred with water
7. filtrationthe resulting solid was filtered
8. washwashed with water
9. customdried
10. customRecrystallization from acetone
11. customgave a grey solid, mp 239-242° C.