反应详情

A mixture of 0.148 g of 4-chloro-5,8-dimethoxy-3-quinolinecarbonitrile, 0.102 g of 4-chloro-2-fluoroaniline, and 5 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 30 minutes. The mixture was cooled and added to 50 ml of water. To this mixture was added sodium carbonate to pH 9. The product was collected, washed with water, dried, and washed with 10 ml of hexanes-ethyl acetate (4:1) to give 0.168 g of 4-(4-chloro-2-fluoro-phenylamino)-5,8-dimethoxy-quinoline-3-carbonitrile as a solid, mp 197-199° C.; mass spectrum (EI, m/e): M 329.7609.

1. temperatureat reflux temperature for 30 minutes
2. temperatureThe mixture was cooled
3. customThe product was collected
4. washwashed with water
5. customdried
6. washwashed with 10 ml of hexanes-ethyl acetate (4:1)