反应详情

温度

210 °C

A stirred mixture of 4-(3-bromophenylamino)-6,7-dimethoxy-3-quinolinecarbonitrile (15.4 g, 40 mmol) and 100 g of pyridine hydrochloride was heated at 210° C. for 20 m, cooled to 0° C., treated with 100 ml of concentrated ammonium hydroxide, and concentrated to dryness. The residue was stirred with 1 L of water, and the resulting amber solid was filtered off, washed with water, and dried; mass spectrum (electrospray, m/e) M+H 356.1, 358.1.

1. temperaturecooled to 0° C.
2. concentrationconcentrated to dryness
3. filtrationthe resulting amber solid was filtered off
4. washwashed with water
5. customdried