4-Chloro-2-fluoroaniline → 4-(4-Chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile

HRID 1935121Notes

Reaction equation

HRID 1935121 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]#[N:15].[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[C:19]([F:24])[CH:18]=1>>[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH:21][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=[CH:4][C:3]=2[C:14]#[N:15])=[C:19]([F:24])[CH:18]=1

Participants

3

Reactant 2

HCID 938984-Chloro-2-fluoroanilineHCID 125594314-Chloro-7-methoxyquinoline-3-carbonitrile

Product 1

HCID 224666624-(4-Chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile

Procedure

In the manner of Example 274 reaction of 4-chloro-7-methoxy-3-quinolinecarbonitrile with 4-chloro-2-fluoroaniline gave the title compound as an amber solid, mp 208-210° C.

Sources & evidence

ORD record
ord-db19c1be48cd41f6a94274127a2e248c
Source dataset
uspto-grants-2002_05
Patent number
US06384051B1

Reaction notes

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