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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1935121Generated: October 31, 2026

4-Chloro-2-fluoroaniline → 4-(4-Chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile

https://huagongshe.com/reaction/1935121

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-2-fluoroanilineHCID 93898—
Reactant4-Chloro-7-methoxyquinoline-3-carbonitrileHCID 12559431—
Product4-(4-Chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrileHCID 22466662—

Reaction Steps

In the manner of Example 274 reaction of 4-chloro-7-methoxy-3-quinolinecarbonitrile with 4-chloro-2-fluoroaniline gave the title compound as an amber solid, mp 208-210° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06384051B1
Source datasetuspto-grants-2002_05
ORD IDord-db19c1be48cd41f6a94274127a2e248c
Source noteuspto-grants-2002_05