3-Bromoaniline → HCID 22466660, compound

HRID 1935181Notes

Reaction equation

HRID 1935181 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]([CH3:14])[CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:15]#[N:16].[Br:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>CCOC(C)=O>[ClH:1].[Br:17][C:18]1[CH:19]=[C:20]([NH:21][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([N:12]([CH3:14])[CH3:13])[CH:10]=3)[N:5]=[CH:4][C:3]=2[C:15]#[N:16])[CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 115623-BromoanilineHCID 22466635HCID 22466635, compound

Product 1

HCID 22466660HCID 22466660, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared from 0.400 g of 4-chloro-6-dimethylaminoquinoline-3-carbonitrile and 3-bromoaniline in the same manner as EXAMPLE 377. The crude product was boiled twice with EtOAc and dried in vacuo (50° C.). The yield of 4-(3-bromophenylamino)-6-dimethylaminoquinoline-3-carbonitrile hydrochloride was 0.621 g as a brown powder: mass spectrum (electrospray, m/e) M+H 366, 368.9.

Workup

  1. customdried in vacuo (50° C.)

Sources & evidence

ORD record
ord-00876531344c417bba92950380599dce
Source dataset
uspto-grants-2002_05
Patent number
US06384051B1

Reaction notes

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